DLX6

Homeobox protein DLX-6 is a protein that in humans is encoded by the DLX6 gene.^[5][6]

DLX6
Identifiers
Aliases	DLX6, distal-less homeobox 6
External IDs	OMIM: 600030; MGI: 101927; HomoloGene: 87855; GeneCards: DLX6; OMA:DLX6 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.3 Start 97,005,553 bp[1] End 97,011,040 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 A1|6 2.83 cM Start 6,863,334 bp[2] End 6,868,568 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell testicle endometrium nucleus accumbens caudate nucleus putamen gonad oocyte sperm endothelial cell Top expressed in superior frontal gyrus Apical ectodermal ridge medial ganglionic eminence lateral septal nucleus hair genital tubercle primary visual cortex olfactory tubercle olfactory bulb dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component nucleus Biological process skeletal system development regulation of transcription, DNA-templated nervous system development embryonic limb morphogenesis epithelial cell differentiation inner ear morphogenesis anatomical structure formation involved in morphogenesis positive regulation of epithelial cell proliferation roof of mouth development head development multicellular organism development regulation of transcription by RNA polymerase II cell differentiation positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1750 13396 Ensembl ENSG00000006377 ENSMUSG00000029754 UniProt P56179 P70397 RefSeq (mRNA) NM_005222 NM_010057 RefSeq (protein) NP_005213 NP_034187 Location (UCSC) Chr 7: 97.01 – 97.01 Mb Chr 6: 6.86 – 6.87 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less gene. This family has at least six members that encode proteins with roles in forebrain and craniofacial development. This gene is in a tail-to-tail configuration with another member of the family, DLX5, on the long arm of chromosome 7.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000006377 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029754 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Simeone A, Acampora D, Pannese M, D'Esposito M, Stornaiuolo A, Gulisano M, Mallamaci A, Kastury K, Druck T, Huebner K, et al. (Apr 1994). "Cloning and characterization of two members of the vertebrate Dlx gene family". Proc Natl Acad Sci U S A. 91 (6): 2250–4. Bibcode:1994PNAS...91.2250S. doi:10.1073/pnas.91.6.2250. PMC 43348. PMID 7907794.
6. "Entrez Gene: DLX6 distal-less homeobox 6".

Further reading

• Crackower MA, Scherer SW, Rommens JM, et al. (1997). "Characterization of the split hand/split foot malformation locus SHFM1 at 7q21.3-q22.1 and analysis of a candidate gene for its expression during limb development". Hum. Mol. Genet. 5 (5): 571–9. doi:10.1093/hmg/5.5.571. PMID 8733122.
• Charité J, McFadden DG, Merlo G, et al. (2001). "Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer". Genes Dev. 15 (22): 3039–49. doi:10.1101/gad.931701. PMC 312822. PMID 11711438.
• Depew MJ, Lufkin T, Rubenstein JL (2002). "Specification of jaw subdivisions by Dlx genes". Science. 298 (5592): 381–5. doi:10.1126/science.1075703. PMID 12193642. S2CID 10274300.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nabi R, Zhong H, Serajee FJ, Huq AH (2004). "No association between single nucleotide polymorphisms in DLX6 and Piccolo genes at 7q21-q22 and autism". Am. J. Med. Genet. B Neuropsychiatr. Genet. 119 (1): 98–101. doi:10.1002/ajmg.b.10012. PMID 12707945. S2CID 39985829.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Schüle B, Li HH, Fisch-Kohl C, et al. (2007). "DLX5 and DLX6 expression is biallelic and not modulated by MeCP2 deficiency". Am. J. Hum. Genet. 81 (3): 492–506. doi:10.1086/520063. PMC 1950824. PMID 17701895.