CLEC4A

C-type lectin domain family 4 member A is a protein that in humans is encoded by the CLEC4A gene.^[5][6]

CLEC4A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5B1W, 5B1X
Identifiers
Aliases	CLEC4A, CLECSF6, DCIR, DDB27, LLIR, CD367, HDCGC13P, C-type lectin domain family 4 member A, hDCIR
External IDs	OMIM: 605306; MGI: 1349412; HomoloGene: 49291; GeneCards: CLEC4A; OMA:CLEC4A - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 8,123,617 bp[1] End 8,138,607 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F2|6 58.18 cM Start 123,083,387 bp[2] End 123,120,958 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood appendix testicle spleen bone marrow bone marrow cells upper lobe of left lung right lung Top expressed in granulocyte stroma of bone marrow tibiofemoral joint spermatid embryo spleen Paneth cell submandibular gland seminiferous tubule blood More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane signaling receptor activity carbohydrate binding calcium ion binding mannose binding metal ion binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process cell surface receptor signaling pathway cell adhesion stimulatory C-type lectin receptor signaling pathway adaptive immune response immune system process innate immune response negative regulation of cytokine production plasmacytoid dendritic cell antigen processing and presentation negative regulation of tumor necrosis factor production CD8-positive, alpha-beta T cell activation antigen processing and presentation of exogenous peptide antigen via MHC class I Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50856 26888 Ensembl ENSG00000111729 ENSMUSG00000030148 UniProt Q9UMR7 Q9QZ15 RefSeq (mRNA) NM_016184 NM_194447 NM_194448 NM_194450 NM_001170332 NM_001170333 NM_011999 RefSeq (protein) NP_057268 NP_919429 NP_919430 NP_919432 NP_001163803 NP_001163804 NP_036129 Location (UCSC) Chr 12: 8.12 – 8.14 Mb Chr 6: 123.08 – 123.12 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response.

Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000111729 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030148 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bates EE, Fournier N, Garcia E, Valladeau J, Durand I, Pin JJ, Zurawski SM, Patel S, Abrams JS, Lebecque S, Garrone P, Saeland S (Sep 1999). "APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif". J Immunol. 163 (4): 1973–83. doi:10.4049/jimmunol.163.4.1973. PMID 10438934.
6. "Entrez Gene: CLEC4A C-type lectin domain family 4, member A".

Further reading

• Drickamer K (1999). "C-type lectin-like domains". Curr. Opin. Struct. Biol. 9 (5): 585–90. doi:10.1016/S0959-440X(99)00009-3. PMID 10508765.
• Huang X, Yuan Z, Chen G, et al. (2001). "Cloning and characterization of a novel ITIM containing lectin-like immunoreceptor LLIR and its two transmembrane region deletion variants". Biochem. Biophys. Res. Commun. 281 (1): 131–40. doi:10.1006/bbrc.2001.4322. PMID 11178971.
• Richard M, Veilleux P, Rouleau M, et al. (2002). "The expression pattern of the ITIM-bearing lectin CLECSF6 in neutrophils suggests a key role in the control of inflammation". J. Leukoc. Biol. 71 (5): 871–80. doi:10.1189/jlb.71.5.871. PMID 11994513. S2CID 36809172.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ebner S, Sharon N, Ben-Tal N (2003). "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily". Proteins. 53 (1): 44–55. doi:10.1002/prot.10440. PMID 12945048. S2CID 30955198.
• Richard M, Thibault N, Veilleux P, et al. (2003). "The ITIM-bearing CLECSF6 (DCIR) is down-modulated in neutrophils by neutrophil activating agents". Biochem. Biophys. Res. Commun. 310 (3): 767–73. doi:10.1016/j.bbrc.2003.09.077. PMID 14550269.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Richard M, Thibault N, Veilleux P, et al. (2006). "Granulocyte macrophage-colony stimulating factor reduces the affinity of SHP-2 for the ITIM of CLECSF6 in neutrophils: a new mechanism of action for SHP-2". Mol. Immunol. 43 (10): 1716–21. doi:10.1016/j.molimm.2005.10.006. PMID 16360206.
• Lorentzen JC, Flornes L, Eklöw C, et al. (2007). "Association of arthritis with a gene complex encoding C-type lectin-like receptors". Arthritis Rheum. 56 (8): 2620–32. doi:10.1002/art.22813. PMID 17665455.

External links

• Human CLEC4A genome location and CLEC4A gene details page in the UCSC Genome Browser.