Ctgf/hcs24 CAESAR

ctgf/hcs24 CAESAR is the name given to the cis-acting RNA element identified in the 3' untranslated region (3'UTR) of the human connective tissue growth factor (CTGF) messenger RNA.^[1] This gene is also known as hypertrophic chondrocyte specific 24 (hcs24).

ctgf/hcs24 CAESAR
Predicted secondary structure and sequence conservation of CAESAR
Identifiers
Symbol	CAESAR
Rfam	RF00172
Other data
RNA type	Cis-reg
Domain(s)	Eukaryota
SO	SO:0000233
PDB structures	PDBe

The importance of the 3'UTR in repressing ctgf gene expression was initially characacterised^[1] and subsequently the minimal RNA element responsible for repression was identified^[2] This element was predicted to form a stable secondary structure, which acts as a post-transcriptional cis-acting element of structure-anchored repression (CAESAR).

The 3'UTR of the ctgf/hcs24 gene in chicken has also been shown to be involved in repression of gene expression.^[3]

References

1. Kubota S, Hattori T, Nakanishi T, Takigawa M (1999). "Involvement of cis-acting repressive element(s) in the 3'-untranslated region of human connective tissue growth factor gene". FEBS Lett. 450 (1–2): 84–88. doi:10.1016/S0014-5793(99)00480-9. PMID 10350062.
2. Kubota S, Kondo S, Eguchi T, et al. (2000). "Identification of an RNA element that confers post-transcriptional repression of connective tissue growth factor/hypertrophic chondrocyte specific 24 (ctgf/hcs24) gene: similarities to retroviral RNA-protein interactions". Oncogene. 19 (41): 4773–4786. doi:10.1038/sj.onc.1203835. PMID 11032028.
3. Mukudai Y, Kubota S, Takigawa M (2003). "Conserved repressive regulation of connective tissue growth factor/hypertrophic chondrocyte-specific gene 24 (ctgf/hcs24) enabled by different elements and factors among vertebrate species". Biol. Chem. 384 (1): 1–9. doi:10.1515/BC.2003.001. PMID 12674494. S2CID 25685816.

External links

• Page for ctgf/hcs24 CAESAR at Rfam