Comins' reagent

The Comins' reagent is a triflyl-donating reagent that is used to synthesize vinyl triflates from the corresponding ketone enolates or dienolates.^[1]

Sample Reaction With Comin's Reagent

Comins' Reagent

Skeletal formula of Comin's Reagent
Names
Preferred IUPAC name N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-((trifluoromethyl)sulfonyl)methanesulfonamide
Identifiers
CAS Number	145100-51-2 N
3D model (JSmol)	Interactive image
ChemSpider	344376
ECHA InfoCard	100.157.321
EC Number	629-110-2
PubChem CID	388544
UNII	WS933U9U66 Y
CompTox Dashboard (EPA)	DTXSID40327763
InChI InChI=1S/C7H3ClF6N2O4S2/c8-4-1-2-5(15-3-4)16(21(17,18)6(9,10)11)22(19,20)7(12,13)14/h1-3H Key: TUFGVZMNGTYAQD-UHFFFAOYSA-N InChI=1/C7H3ClF6N2O4S2/c8-4-1-2-5(15-3-4)16(21(17,18)6(9,10)11)22(19,20)7(12,13)14/h1-3H Key: TUFGVZMNGTYAQD-UHFFFAOYAK
SMILES O=S(=O)(N(c1ccc(Cl)cn1)S(=O)(=O)C(F)(F)F)C(F)(F)F
Properties
Chemical formula	C7H3ClF6N2O4S2
Molar mass	392.67 g·mol−1
Appearance	White solid
Melting point	45 °C (113 °F; 318 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

It was first reported in 1992 by Daniel Comins.^[2] The vinyl triflates prepared are useful as substrates in the Suzuki reaction.^[3]

See also

• Bis(trifluoromethanesulfonyl)aniline