Cenani–Lenz syndactylism, also known as Cenani–Lenz syndrome or Cenani–syndactylism,[1][2] is an autosomal recessive congenital malformation syndrome[3][4] involving both upper and lower extremities.
Cenani–Lenz syndactylism | |
---|---|
Other names | Syndactyly type 7 |
![]() | |
Specialty | Medical genetics ![]() |
Presentation
It is characterized by a nearly symmetrical presence of a spoon hand (classical type) or, more frequently, an oligodactylous hand. Individuals with this syndrome present the following symptoms: carpal, metacarpal and digital synostoses, disorganization of carpal bones, numeric reduction of digital rays and toe syndactyly. Additionally, other symptoms may include radioulnar synostosis, brachymesomelia, radius head dislocation, metatarsal synostoses and numeric reduction of rays.[citation needed]
Cause
Cenani–Lenz syndactylism is inherited in an autosomal recessive manner.[1] This means the defective gene responsible for the disorder is located on an autosome, and two copies of the defective gene (one inherited from each parent) are required in order to be born with the disorder. The parents of an individual with an autosomal recessive disorder both carry one copy of the defective gene, but usually do not experience any signs or symptoms of the disorder.[citation needed]
In a test of the theory that the locus associated with the disorder was at 15q13-q14, FMN1 and GREM1 were eliminated as candidates.[5] It is associated with LRP4.[6]
Treatment
![]() | This section is empty. You can help by adding to it. (July 2017) |
Eponym
The syndrome is named after Turkish (Asim Cenani) and German (Widukind Lenz) medical geneticists.[7][8]
References
Wikiwand in your browser!
Seamless Wikipedia browsing. On steroids.
Every time you click a link to Wikipedia, Wiktionary or Wikiquote in your browser's search results, it will show the modern Wikiwand interface.
Wikiwand extension is a five stars, simple, with minimum permission required to keep your browsing private, safe and transparent.