Casein kinase 1, alpha 1

Casein kinase I isoform alpha is an enzyme that in humans is encoded by the CSNK1A1 gene.^[5]

CSNK1A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5FQD
Identifiers
Aliases	CSNK1A1, CK1, CK1a, CKIa, HEL-S-77p, HLCDGP1, PRO2975, casein kinase 1 alpha 1
External IDs	OMIM: 600505; MGI: 1934950; HomoloGene: 111694; GeneCards: CSNK1A1; OMA:CSNK1A1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q32 Start 149,492,982 bp[1] End 149,551,471 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E1 Start 61,688,345 bp[2] End 61,723,132 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium islet of Langerhans gallbladder ganglionic eminence smooth muscle tissue epithelium of colon ventricular zone nipple Achilles tendon pylorus Top expressed in renal corpuscle atrioventricular valve cumulus cell medullary collecting duct medial ganglionic eminence left lung lobe Gonadal ridge molar endocardial cushion pineal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding protein binding ATP binding kinase activity protein serine/threonine kinase activity Cellular component cytoplasm centrosome nuclear speck mRNA cleavage and polyadenylation specificity factor complex membrane keratin filament chromosome microtubule organizing center chromosome, centromeric region cytoskeleton beta-catenin destruction complex kinetochore nucleus cytosol cilium cell projection ciliary basal body ribonucleoprotein complex Biological process regulation of GTP binding Golgi organization phosphorylation cell division protein phosphorylation cell surface receptor signaling pathway peptidyl-serine phosphorylation phagocytosis intermediate filament cytoskeleton organization cell cycle negative regulation of canonical Wnt signaling pathway positive regulation of proteasomal ubiquitin-dependent protein catabolic process signal transduction proteasome-mediated ubiquitin-dependent protein catabolic process beta-catenin destruction complex assembly regulation of cell shape beta-catenin destruction complex disassembly Wnt signaling pathway cell morphogenesis peptidyl-threonine phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1452 93687 Ensembl ENSG00000113712 ENSMUSG00000024576 UniProt P48729 Q6PJ87 RefSeq (mRNA) NM_001025105 NM_001271741 NM_001271742 NM_001892 NM_146087 NM_001357498 NM_001357499 NM_001357500 RefSeq (protein) NP_001020276 NP_001258670 NP_001258671 NP_001883 NP_666199 NP_001344427 NP_001344428 NP_001344429 Location (UCSC) Chr 5: 149.49 – 149.55 Mb Chr 18: 61.69 – 61.72 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Casein kinase 1, alpha 1 has been shown to interact with Centaurin, alpha 1^[6][7] and AXIN1.^[8]

See also

• Casein kinase 1

References

1. GRCh38: Ensembl release 89: ENSG00000113712 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024576 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tapia C, Featherstone T, Gómez C, Taillon-Miller P, Allende CC, Allende JE (Aug 1994). "Cloning and chromosomal localization of the gene coding for human protein kinase CK1". FEBS Letters. 349 (2): 307–12. doi:10.1016/0014-5793(94)00679-2. PMID 8050587. S2CID 19071414.
6. Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS Letters. 517 (1–3): 167–71. doi:10.1016/S0014-5793(02)02614-5. PMID 12062430. S2CID 84792445.
7. Dubois T, Kerai P, Zemlickova E, Howell S, Jackson TR, Venkateswarlu K, Cullen PJ, Theibert AB, Larose L, Roach PJ, Aitken A (Jun 2001). "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins". The Journal of Biological Chemistry. 276 (22): 18757–64. doi:10.1074/jbc.M010005200. PMID 11278595.
8. Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC (May 2002). "Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways". The Journal of Biological Chemistry. 277 (20): 17706–12. doi:10.1074/jbc.M111982200. PMID 11884395.

Further reading

• Veis A, Sfeir C, Wu CB (1998). "Phosphorylation of the proteins of the extracellular matrix of mineralized tissues by casein kinase-like activity". Critical Reviews in Oral Biology and Medicine. 8 (4): 360–79. doi:10.1177/10454411970080040101. PMID 9391750.
• Giaccia AJ, Kastan MB (Oct 1998). "The complexity of p53 modulation: emerging patterns from divergent signals". Genes & Development. 12 (19): 2973–83. doi:10.1101/gad.12.19.2973. PMID 9765199.