Cyclic nucleotide-gated channel alpha 4

Cyclic nucleotide-gated cation channel alpha-4 is a protein that in humans is encoded by the CNGA4 gene.^[5][6][7]

CNGA4
Identifiers
Aliases	CNGA4, CNCA2, CNG-4, CNG4, CNG5, CNGB2, OCNC2, OCNCBETA, OCNCb, Cyclic nucleotide-gated channel alpha 4, cyclic nucleotide gated channel alpha 4, cyclic nucleotide gated channel subunit alpha 4
External IDs	OMIM: 609472; MGI: 2664099; HomoloGene: 13579; GeneCards: CNGA4; OMA:CNGA4 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 6,234,765 bp[1] End 6,244,479 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E3 Start 105,053,775 bp[2] End 105,057,949 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad right uterine tube testicle bronchial epithelial cell olfactory zone of nasal mucosa left testis right testis C1 segment right lung mucosa of paranasal sinus Top expressed in olfactory epithelium zygote secondary oocyte granulocyte primary oocyte dentate gyrus of hippocampal formation granule cell spermatid superior frontal gyrus primary visual cortex testicle More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding cAMP binding voltage-gated potassium channel activity ion channel activity intracellular cAMP-activated cation channel activity intracellular cGMP-activated cation channel activity cGMP binding Cellular component Golgi-associated vesicle membrane integral component of membrane Golgi membrane membrane ciliary membrane integral component of plasma membrane Biological process transmembrane transport response to stimulus sensory perception of smell ion transport ion transmembrane transport regulation of membrane potential potassium ion transmembrane transport cation transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1262 233649 Ensembl ENSG00000132259 ENSMUSG00000030897 UniProt Q8IV77 Q3UW12 RefSeq (mRNA) NM_001037329 NM_001033317 RefSeq (protein) NP_001032406 NP_001028489 Location (UCSC) Chr 11: 6.23 – 6.24 Mb Chr 7: 105.05 – 105.06 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001).[supplied by OMIM]^[7]

See also

• Cyclic nucleotide-gated ion channel

References

1. GRCh38: Ensembl release 89: ENSG00000132259 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030897 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bradley J, Frings S, Yau KW, Reed R (Dec 2001). "Nomenclature for Ion channel Subunits". Science. 294 (5549): 2095–6. doi:10.1126/science.294.5549.2095. PMC 2901924. PMID 11764791.
6. Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol Rev. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102. S2CID 45853869.
7. "Entrez Gene: CNGA4 cyclic nucleotide gated channel alpha 4".

Further reading

• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kelliher KR, Ziesmann J, Munger SD, et al. (2003). "Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4299–304. Bibcode:2003PNAS..100.4299K. doi:10.1073/pnas.0736071100. PMC 153087. PMID 12649326.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Munger SD, Lane AP, Zhong H, et al. (2002). "Central Role of the CNGA4 Channel Subunit in Ca2+-Calmodulin–Dependent Odor Adaptation". Science. 294 (5549): 2172–5. doi:10.1126/science.1063224. PMC 2885906. PMID 11739959.
• Sautter A, Zong X, Hofmann F, Biel M (1998). "An isoform of the rod photoreceptor cyclic nucleotide-gated channel β subunit expressed in olfactory neurons". Proc. Natl. Acad. Sci. U.S.A. 95 (8): 4696–701. Bibcode:1998PNAS...95.4696S. doi:10.1073/pnas.95.8.4696. PMC 22553. PMID 9539801.

External links

• CNGA4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.