Calcineurin B homologous protein 1

Calcineurin B homologous protein 1 is a protein encoded in humans by the CHP1 gene (formerly CHP).^[5]

CHP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E30
Identifiers
Aliases	CHP1, CHP, SLC9A1BP, Sid470p, p22, p24, calcineurin like EF-hand protein 1, SPAX9
External IDs	OMIM: 606988; MGI: 1927185; HomoloGene: 5235; GeneCards: CHP1; OMA:CHP1 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.1 Start 41,230,839 bp[1] End 41,281,887 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E5 Start 119,378,178 bp[2] End 119,417,508 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of colon mucosa of sigmoid colon jejunal mucosa vulva mucosa of transverse colon nasal epithelium mucosa of ileum duodenum mucosa of pharynx gums Top expressed in seminal vesicula dorsomedial hypothalamic nucleus decidua lateral septal nucleus pontine nuclei ventral tegmental area ventromedial nucleus lobe of prostate subiculum anterior amygdaloid area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding transporter activity microtubule binding protein kinase inhibitor activity metal ion binding calcium-dependent protein binding potassium channel regulator activity kinase binding protein binding Cellular component cytoplasm cytosol membrane focal adhesion microtubule cytoskeleton Golgi membrane plasma membrane transport vesicle endoplasmic reticulum extracellular exosome cytoskeleton endomembrane system nucleus endoplasmic reticulum-Golgi intermediate compartment Biological process negative regulation of protein phosphorylation positive regulation of protein glycosylation negative regulation of calcineurin-NFAT signaling cascade hyaluronan catabolic process negative regulation of protein autophosphorylation negative regulation of protein kinase activity positive regulation of sodium:proton antiporter activity negative regulation of phosphatase activity small GTPase mediated signal transduction protein stabilization cellular response to acidic pH membrane fusion regulation of intracellular pH positive regulation of protein transport negative regulation of protein ubiquitination potassium ion transport protein complex oligomerization microtubule bundle formation cytoplasmic microtubule organization protein export from nucleus membrane docking regulation of neuron death protein transport membrane organization negative regulation of NF-kappaB transcription factor activity calcium-ion regulated exocytosis positive regulation of protein targeting to membrane negative regulation of protein import into nucleus transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11261 56398 Ensembl ENSG00000187446 ENSMUSG00000014077 UniProt Q99653 P61022 RefSeq (mRNA) NM_007236 NM_019769 RefSeq (protein) NP_009167 NP_062743 Location (UCSC) Chr 15: 41.23 – 41.28 Mb Chr 2: 119.38 – 119.42 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a phosphoprotein that binds to the sodium-hydrogen exchangers (NHEs). This protein serves as an essential cofactor which supports the physiological activity of NHE family members. It has protein sequence similarity to calcineurin B and it is also known to be an endogenous inhibitor of calcineurin activity.^[5]

Interactions

Calcineurin B homologous protein 1 has been shown to interact with

• sodium-hydrogen antiporter 1,^[6][7][8]
• sodium-hydrogen antiporter 3,^[6] and
• sodium-hydrogen anti porter 9.^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000187446 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000014077 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CHP calcium binding protein P22".
6. Inoue H, Nakamura Y, Nagita M, Takai T, Masuda M, Nakamura N, Kanazawa H (Feb 2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium". Biological & Pharmaceutical Bulletin. 26 (2): 148–55. doi:10.1248/bpb.26.148. PMID 12576672.
7. Lin X, Barber DL (Oct 1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proceedings of the National Academy of Sciences of the United States of America. 93 (22): 12631–6. Bibcode:1996PNAS...9312631L. doi:10.1073/pnas.93.22.12631. PMC 38044. PMID 8901634.
8. Pang T, Su X, Wakabayashi S, Shigekawa M (May 2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". The Journal of Biological Chemistry. 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981.
9. Zhang-James Y, DasBanerjee T, Sagvolden T, Middleton FA, Faraone SV (Dec 2011). "SLC9A9 mutations, gene expression, and protein-protein interactions in rat models of attention-deficit/hyperactivity disorder". American Journal of Medical Genetics Part B. 156B (7): 835–43. doi:10.1002/ajmg.b.31229. PMC 3168688. PMID 21858920.

Further reading

• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (Sep 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
• Barroso MR, Bernd KK, DeWitt ND, Chang A, Mills K, Sztul ES (Apr 1996). "A novel Ca2+-binding protein, p22, is required for constitutive membrane traffic". The Journal of Biological Chemistry. 271 (17): 10183–7. doi:10.1074/jbc.271.17.10183. PMID 8626580.
• Lin X, Barber DL (Oct 1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proceedings of the National Academy of Sciences of the United States of America. 93 (22): 12631–6. Bibcode:1996PNAS...9312631L. doi:10.1073/pnas.93.22.12631. PMC 38044. PMID 8901634.
• Lin X, Sikkink RA, Rusnak F, Barber DL (Dec 1999). "Inhibition of calcineurin phosphatase activity by a calcineurin B homologous protein". The Journal of Biological Chemistry. 274 (51): 36125–31. doi:10.1074/jbc.274.51.36125. PMID 10593895.
• Pang T, Su X, Wakabayashi S, Shigekawa M (May 2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". The Journal of Biological Chemistry. 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981.
• Matsumoto M, Miyake Y, Nagita M, Inoue H, Shitakubo D, Takemoto K, Ohtsuka C, Murakami H, Nakamura N, Kanazawa H (Aug 2001). "A serine/threonine kinase which causes apoptosis-like cell death interacts with a calcineurin B-like protein capable of binding Na(+)/H(+) exchanger". Journal of Biochemistry. 130 (2): 217–25. doi:10.1093/oxfordjournals.jbchem.a002975. PMID 11481038.
• Nakamura N, Miyake Y, Matsushita M, Tanaka S, Inoue H, Kanazawa H (Sep 2002). "KIF1Bbeta2, capable of interacting with CHP, is localized to synaptic vesicles". Journal of Biochemistry. 132 (3): 483–91. doi:10.1093/oxfordjournals.jbchem.a003246. PMID 12204119.
• Pang T, Wakabayashi S, Shigekawa M (Nov 2002). "Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchanger". The Journal of Biological Chemistry. 277 (46): 43771–7. doi:10.1074/jbc.M208313200. PMID 12226101.
• Inoue H, Nakamura Y, Nagita M, Takai T, Masuda M, Nakamura N, Kanazawa H (Feb 2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium". Biological & Pharmaceutical Bulletin. 26 (2): 148–55. doi:10.1248/bpb.26.148. PMID 12576672.
• Pang T, Hisamitsu T, Mori H, Shigekawa M, Wakabayashi S (Mar 2004). "Role of calcineurin B homologous protein in pH regulation by the Na+/H+ exchanger 1: tightly bound Ca2+ ions as important structural elements". Biochemistry. 43 (12): 3628–36. doi:10.1021/bi0360004. PMID 15035633.
• Andrade J, Pearce ST, Zhao H, Barroso M (Dec 2004). "Interactions among p22, glyceraldehyde-3-phosphate dehydrogenase and microtubules". The Biochemical Journal. 384 (Pt 2): 327–36. doi:10.1042/BJ20040622. PMC 1134116. PMID 15312048.
• Ben Ammar Y, Takeda S, Sugawara M, Miyano M, Mori H, Wakabayashi S (Oct 2005). "Crystallization and preliminary crystallographic analysis of the human calcineurin homologous protein CHP2 bound to the cytoplasmic region of the Na+/H+ exchanger NHE1". Acta Crystallographica Section F. 61 (Pt 10): 956–8. doi:10.1107/S1744309105030836. PMC 1991313. PMID 16511206.
• Mishima M, Wakabayashi S, Kojima C (Jan 2007). "Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1". The Journal of Biological Chemistry. 282 (4): 2741–51. doi:10.1074/jbc.M604092200. PMID 17050540.

External links

• Human CHP1 genome location and CHP1 gene details page in the UCSC Genome Browser.