CDS1 (gene)

Phosphatidate cytidylyltransferase 1 is an enzyme that in humans is encoded by the CDS1 gene.^[5][6][7]

CDS1
Identifiers
Aliases	CDS1, CDS, CDP-diacylglycerol synthase 1, CDS 1
External IDs	OMIM: 603548; MGI: 1921846; HomoloGene: 68173; GeneCards: CDS1; OMA:CDS1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.23 Start 84,583,127 bp[1] End 84,651,334 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E5 Start 101,912,996 bp[2] End 101,971,724 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell secondary oocyte caput epididymis amniotic fluid jejunal mucosa mucosa of paranasal sinus corpus epididymis middle temporal gyrus nasal epithelium Brodmann area 23 Top expressed in transitional epithelium of urinary bladder neural layer of retina jejunum nasal epithelium olfactory epithelium ileum retinal pigment epithelium vestibular membrane of cochlear duct otolith organ utricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity, transferring phosphorus-containing groups nucleotidyltransferase activity diacylglycerol cholinephosphotransferase activity transferase activity phosphatidate cytidylyltransferase activity Cellular component membrane integral component of membrane endoplasmic reticulum endoplasmic reticulum membrane Biological process phototransduction phospholipid biosynthetic process phosphatidylglycerol biosynthetic process CDP-diacylglycerol biosynthetic process lipid metabolism signal transduction phosphatidylinositol biosynthetic process CDP-choline pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1040 74596 Ensembl ENSG00000163624 ENSMUSG00000029330 UniProt Q92903 P98191 RefSeq (mRNA) NM_001263 NM_173370 RefSeq (protein) NP_001254 NP_775546 Location (UCSC) Chr 4: 84.58 – 84.65 Mb Chr 5: 101.91 – 101.97 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin.^[8][9] and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 (this gene) and a second (CDS2) to 20p13.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000163624 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029330 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Halford S, Dulai KS, Daw SC, Fitzgibbon J, Hunt DM (November 1998). "Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes". Genomics. 54 (1): 140–4. doi:10.1006/geno.1998.5547. PMID 9806839.
6. Weeks R, Dowhan W, Shen H, Balantac N, Meengs B, Nudelman E, Leung DW (March 1997). "Isolation and expression of an isoform of human CDP-diacylglycerol synthase cDNA". DNA and Cell Biology. 16 (3): 281–9. doi:10.1089/dna.1997.16.281. PMID 9115637.
7. "Entrez Gene: CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1".
8. Nowicki M, Müller F, Frentzen M (April 2005). "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161–5. doi:10.1016/j.febslet.2005.03.007. PMID 15811335. S2CID 21937549.
9. Nowicki M (2006). Characterization of the Cardiolipin Synthase from Arabidopsis thaliana (Ph.D. Thesis thesis). RWTH-Aachen University. Archived from the original on 2011-10-05. Retrieved 2011-07-11.

Further reading

• Liu Y, Virshup DM, White RL, Hsu LC (November 2002). "Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha". Cancer Research. 62 (22): 6357–61. PMID 12438214.
• Volta M, Bulfone A, Gattuso C, Rossi E, Mariani M, Consalez GG, et al. (January 1999). "Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene". Genomics. 55 (1): 68–77. doi:10.1006/geno.1998.5610. PMID 9889000.
• Lykidis A, Jackson PD, Rock CO, Jackowski S (December 1997). "The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content". The Journal of Biological Chemistry. 272 (52): 33402–9. doi:10.1074/jbc.272.52.33402. PMID 9407135.
• Heacock AM, Uhler MD, Agranoff BW (November 1996). "Cloning of CDP-diacylglycerol synthase from a human neuronal cell line" (PDF). Journal of Neurochemistry. 67 (5): 2200–3. doi:10.1046/j.1471-4159.1996.67052200.x. hdl:2027.42/65959. PMID 8863531. S2CID 2805319.

External links

• Human CDS1 genome location and CDS1 gene details page in the UCSC Genome Browser.