T-cell surface glycoprotein CD3 zeta chain

T-cell surface glycoprotein CD3 zeta chain also known as T-cell receptor T3 zeta chain or CD247 (Cluster of Differentiation 247) is a protein that in humans is encoded by the CD247 gene.^[5]

CD247
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1TCE, 1YGR, 2HAC, 2OQ1, 3IK5, 3IOZ, 4XZ1
Identifiers
Aliases	CD247, CD3-ZETA, CD3H, CD3Q, CD3Z, IMD25, T3Z, TCRZ, CD247 molecule, CD3zeta
External IDs	OMIM: 186780; MGI: 88334; HomoloGene: 12818; GeneCards: CD247; OMA:CD247 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q24.2 Start 167,430,640 bp[1] End 167,518,610 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H2.3|1 73.14 cM Start 165,616,250 bp[2] End 165,704,846 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte thymus blood gonad lymph node spleen appendix testicle bone marrow bone marrow cells Top expressed in thymus mesenteric lymph nodes blood aortic valve ascending aorta tail of embryo spleen subcutaneous adipose tissue genital tubercle spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transmembrane signaling receptor activity identical protein binding protein homodimerization activity protein tyrosine kinase binding Cellular component cytoplasm integral component of membrane alpha-beta T cell receptor complex plasma membrane T cell receptor complex membrane Biological process cell surface receptor signaling pathway mitigation of host defenses by virus T cell receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis regulation of immune response viral process protein homotetramerization protein homotrimerization adaptive immune response immune system process interleukin-2 production positive regulation of protein localization to cell surface Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 919 12503 Ensembl ENSG00000198821 ENSMUSG00000005763 UniProt P20963 Q3UU54 P24161 RefSeq (mRNA) NM_000734 NM_198053 NM_001378515 NM_001378516 NM_001113391 NM_001113392 NM_001113393 NM_001113394 NM_031162 RefSeq (protein) NP_000725 NP_932170 NP_001365444 NP_001365445 NP_112439.1 NP_001106862.1 NP_001106862 NP_001106863 NP_001106864 NP_112439 Location (UCSC) Chr 1: 167.43 – 167.52 Mb Chr 1: 165.62 – 165.7 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Some older literature mention a similar protein called "CD3 eta" in mice. It is now understood to be an isoform differing in the last exon.^[6]

Genomics

The gene is located on the long arm of chromosome 1 at location 1q22-q25 on the Crick (negative) strand. The encoded protein is 164 amino acids long with a predicted weight of 18.696 kiloDaltons.

Function

T-cell receptor zeta (ζ), together with T-cell receptor alpha/beta and gamma/delta heterodimers and CD3-gamma, -delta, and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[7]

Interactions

CD247 has been shown to interact with Janus kinase 3^[8] and Protein unc-119 homolog.^[9]

See also

• Cluster of differentiation
• ZAP70

References

1. GRCh38: Ensembl release 89: ENSG00000198821 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005763 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Weissman AM, Hou D, Orloff DG, Modi WS, Seuanez H, O'Brien SJ, Klausner RD (December 1988). "Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex". Proc. Natl. Acad. Sci. U.S.A. 85 (24): 9709–13. Bibcode:1988PNAS...85.9709W. doi:10.1073/pnas.85.24.9709. PMC 282845. PMID 2974162.
6. Clayton LK, D'Adamio L, Howard FD, Sieh M, Hussey RE, Koyasu S, Reinherz EL (June 1991). "CD3 eta and CD3 zeta are alternatively spliced products of a common genetic locus and are transcriptionally and/or post-transcriptionally regulated during T-cell development". Proceedings of the National Academy of Sciences of the United States of America. 88 (12): 5202–6. doi:10.1073/pnas.88.12.5202. PMC 51840. PMID 1828894.
7. "Entrez Gene: CD247 CD247 molecule".
8. Tomita K, Saijo K, Yamasaki S, Iida T, Nakatsu F, Arase H, Ohno H, Shirasawa T, Kuriyama T, O'Shea JJ, Saito T (Jul 2001). "Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex". J. Biol. Chem. 276 (27): 25378–85. doi:10.1074/jbc.M011363200. PMID 11349123.
9. Gorska MM, Stafford SJ, Cen O, Sur S, Alam R (Feb 2004). "Unc119, a novel activator of Lck/Fyn, is essential for T cell activation". J. Exp. Med. 199 (3): 369–79. doi:10.1084/jem.20030589. PMC 2211793. PMID 14757743.

Further reading

• Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef". EMBO Rep. 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMC 1083955. PMID 11463741.
• Greenway AL, Holloway G, McPhee DA, Ellis P, Cornall A, Lidman M (2004). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication". J. Biosci. 28 (3): 323–35. doi:10.1007/BF02970151. PMID 12734410. S2CID 33749514.
• Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects". Curr. HIV Res. 4 (1): 57–64. doi:10.2174/157016206775197583. PMID 16454711.

External links

• CD247+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CD247 genome location and CD247 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: P20963 (Human T-cell surface glycoprotein CD3 zeta chain (CD247)) at the PDBe-KB.