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Chemical compound From Wikipedia, the free encyclopedia
Broxaterol is a β2 adrenoreceptor agonist.[1] It is part of a class of drugs that affect the smooth muscle receptors in the body, often in use cases for respiratory disease that respond to this type of treatment.
Names | |
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IUPAC name
1-(3-Bromo-5-isoxazolyl)-2-(tert-butylamino)ethanol | |
Identifiers | |
3D model (JSmol) |
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ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.071.338 |
MeSH | Broxaterol |
PubChem CID |
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UNII | |
CompTox Dashboard (EPA) |
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Properties | |
C9H15BrN2O2 | |
Molar mass | 263.135 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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The 1,3-dipolar cycloaddition between bromonitrile oxide, produced in situ from dibromoformaldoxime, and 3-butyn-2-one gives a mixture of isoxazoles, mainly the isomer shown required for broxaterol. Selective α-bromination of the acetyl group with pyridinium tribromide gives a bromoketone whose carbonyl group is reduced with sodium borohydride to produce a bromoethanol derivative. Treatment of this with tert-butylamine yields broxaterol.[2][3][4][5]
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