Brereton is a surname. Notable people with the surname include:
- Alexander Picton Brereton (1892–1976), Canadian recipient of the Victoria Cross
- Ben Brereton Díaz (born 1999), Chilean footballer
- Bridget Brereton (born 1946), Trinidad and Tobago-based historian
- Cuthbert A. Brereton (1850–1910), British civil engineer
- Dan Brereton (born 1965), American artist and illustrator
- Dermott Brereton (born 1964), Australian rules footballer
- Ernest Le Gay Brereton (1869–1932), Australian mining engineer and academic
- Frederick Sadleir Brereton (1852–1957), British author
- Henry E. H. Brereton (1865–1957), New York politician
- Jack Brereton (born 1991), British politician
- John Brereton (disambiguation), several people
- Joseph Lloyd Brereton (1822–1901), English educational reformer and writer
- Kevin Brereton (born 1972), Canadian singer, songwriter and record producer
- Laurie Brereton (born 1946), Australian politician
- Lewis H. Brereton (1890–1967), American military aviation pioneer
- Mocky Brereton, New Zealand rugby league footballer
- Patrick Brereton, author and academic at Dublin City University
- Paul Brereton (born 1957), Australian judge and soldier
- Robert Maitland Brereton (1834–1911), English railway engineer
- Robert Pearson Brereton (1818–1894), British engineer and colleague of Isambard Kingdom Brunel
- Thomas Brereton (1782–1831), Irish soldier, governor of Senegal
- William Brereton (disambiguation), several people
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