Protein BTG3

Protein BTG3 is a protein that in humans is encoded by the BTG3 gene.^[5][6]

BTG3
Identifiers
Aliases	BTG3, ANA, TOB5, TOB55, TOFA, BTG family member 3, BTG anti-proliferation factor 3, ANA/APRO4
External IDs	OMIM: 605674; MGI: 109532; HomoloGene: 4953; GeneCards: BTG3; OMA:BTG3 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q21.1 Start 17,593,653 bp[1] End 17,612,945 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C3.1 Start 78,129,525 bp[2] End 78,174,080 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone cartilage tissue corpus epididymis ganglionic eminence parotid gland gingival epithelium islet of Langerhans right uterine tube beta cell lower lobe of lung Top expressed in pancreas epiblast lung islet of Langerhans embryo ventricular zone embryo placenta lip ovary More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm nucleus Biological process negative regulation of cell population proliferation negative regulation of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10950 12228 Ensembl ENSG00000281484 ENSG00000154640 ENSMUSG00000022863 UniProt Q14201 Q6IAU3 P50615 RefSeq (mRNA) NM_001130914 NM_006806 NM_001297747 NM_009770 RefSeq (protein) NP_001124386 NP_006797 NP_001124386.1 NP_006797.3 NP_001284676 NP_033900 Location (UCSC) Chr 21: 17.59 – 17.61 Mb Chr 16: 78.13 – 78.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system.^[6]

References

1. ENSG00000154640 GRCh38: Ensembl release 89: ENSG00000281484, ENSG00000154640 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022863 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yoshida Y, Matsuda S, Ikematsu N, Kawamura-Tsuzuku J, Inazawa J, Umemori H, Yamamoto T (Jun 1998). "ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system". Oncogene. 16 (20): 2687–93. doi:10.1038/sj.onc.1201805. PMID 9632145. S2CID 10053424.
6. "Entrez Gene: BTG3 BTG family, member 3".

External links

• Human BTG3 genome location and BTG3 gene details page in the UCSC Genome Browser.

Further reading

• Matsuda S, Rouault J, Magaud J, Berthet C (2001). "In search of a function for the TIS21/PC3/BTG1/TOB family". FEBS Lett. 497 (2–3): 67–72. doi:10.1016/S0014-5793(01)02436-X. PMID 11377414. S2CID 43120613.
• Guéhenneux F, Duret L, Callanan MB, Bouhas R, Hayette S, Berthet C, Samarut C, Rimokh R, Birot AM (1997). "Cloning of the mouse BTG3 gene and definition of a new gene family (the BTG family) involved in the negative control of the cell cycle". Leukemia. 11 (3): 370–5. doi:10.1038/sj.leu.2400599. PMID 9067576. S2CID 12912055.
• Hattori M, Fujiyama A, Taylor TD, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
• Birot A, Duret L, Bartholin L, Santalucia B, Tigaud I, Magaud JP, Rouault JP (2000). "Identification and molecular analysis of BANP". Gene. 253 (2): 189–96. doi:10.1016/S0378-1119(00)00244-4. PMID 10940556.
• Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex". Jpn. J. Cancer Res. 92 (6): 592–6. doi:10.1111/j.1349-7006.2001.tb01135.x. PMC 5926753. PMID 11429045.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Ou YH, Chung PH, Hsu FF, Sun TP, Chang WY, Shieh SY (2007). "The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1". EMBO J. 26 (17): 3968–80. doi:10.1038/sj.emboj.7601825. PMC 1994125. PMID 17690688.