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Atezolizumab/hyaluronidase, sold under the brand name Tecentriq Hybreza, is a fixed-dose combination medication used for the treatment of non-small cell lung cancer, small cell lung cancer, hepatocellular carcinoma, melanoma, and alveolar soft part sarcoma.[1][2] It contains atezolizumab, a programmed death-ligand 1 (PD-L1) blocking monoclonal antibody; and hyaluronidase (human recombinant), an endoglycosidase.[1] It is taken by subcutaneous injection.[1]
| Combination of | |
|---|---|
| Atezolizumab | Monoclonal antibody |
| Hyaluronidase | Endoglycosidase |
| Clinical data | |
| Trade names | Tecentriq Hybreza |
| AHFS/Drugs.com | Tecentriq-hybreza |
| License data | |
| Routes of administration | Subcutaneous |
| ATC code |
|
| Legal status | |
| Legal status | |
The most common adverse reactions include fatigue, musculoskeletal pain, cough, dyspnea, and decreased appetite.[1][2]
Atezolizumab/hyaluronidase was approved for medical use in the United States in September 2024.[1][2][3][4]
Medical uses
Atezolizumab/hyaluronidase is a subcutaneous injection version of atezolizumab for all the adult indications as the intravenous formulation of atezolizumab including non-small cell lung cancer, small cell lung cancer, hepatocellular carcinoma, melanoma, and alveolar soft part sarcoma.[2]
History
The subcutaneous injection of atezolizumab and hyaluronidase was evaluated in IMscin001 (NCT03735121), an open-label, multi-center, international, randomized trial in adults with locally advanced or metastatic non-small cell lung cancer who were not previously exposed to cancer immunotherapy and who had disease progression following treatment with platinum-based chemotherapy.[2] A total of 371 participants were randomized (2:1) to receive subcutaneous atezolizumab and hyaluronidase or intravenous atezolizumab until disease progression or unacceptable toxicity.[2]
References
External links
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