5-Fluoroorotic acid (5FOA) is a fluorinated derivative of the pyrimidine precursor orotic acid. It is used in yeast genetics to select for the absence of the URA3 gene, which encodes the enzyme for the decarboxylation of 5-fluoroorotic acid to 5-fluorouracil, a toxic metabolite.[1] It has also been used in diatom selection.[2]

Quick Facts Names, Identifiers ...
5-Fluoroorotic acid
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Names
Preferred IUPAC name
5-Fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.010.798 Edit this at Wikidata
UNII
  • InChI=1S/C5H3FN2O4/c6-1-2(4(10)11)7-5(12)8-3(1)9/h(H,10,11)(H2,7,8,9,12)
    Key: SEHFUALWMUWDKS-UHFFFAOYSA-N
  • InChI=1/C5H3FN2O4/c6-1-2(4(10)11)7-5(12)8-3(1)9/h(H,10,11)(H2,7,8,9,12)
    Key: SEHFUALWMUWDKS-UHFFFAOYAV
  • C1(=C(NC(=O)NC1=O)C(=O)O)F
Properties
C5H3FN2O4
Molar mass 174.087 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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See also

References

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