5-Fluoroorotic acid (5FOA) is a fluorinated derivative of the pyrimidine precursor orotic acid. It is used in yeast genetics to select for the absence of the URA3 gene, which encodes the enzyme for the decarboxylation of 5-fluoroorotic acid to 5-fluorouracil, a toxic metabolite.[1] It has also been used in diatom selection.[2]
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Names | |
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Preferred IUPAC name
5-Fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid | |
Identifiers | |
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3D model (JSmol) |
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ChemSpider | |
ECHA InfoCard | 100.010.798 |
PubChem CID |
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UNII | |
CompTox Dashboard (EPA) |
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Properties | |
C5H3FN2O4 | |
Molar mass | 174.087 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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See also
References
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