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Daniela Di Toro and Aniek van Koot defeated the three-time defending champion Esther Vergeer and her partner Sharon Walraven in the final, 3–6, 6–3, [10–4] to win the women's doubles wheelchair tennis title at the 2010 French Open. With the win, they ended Vergeer's 19-major winning streak, dating back at the 2002 French Open.[citation needed]
| Wheelchair women's doubles | |
|---|---|
| 2010 French Open | |
| Champions |  Daniela Di Toro  Aniek van Koot |
| Runners-up | Esther Vergeer Sharon Walraven |
| Score | 3–6, 6–3, [10–4] |
Korie Homan and Esther Vergeer were the reigning champions, but Homan did not compete this year.
Daniela Di Toro / 
Aniek van Koot (champions)- Esther Vergeer / Sharon Walraven (final)
Key
- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- SE = Special exempt
- PR = Protected ranking
- ITF = ITF entry
- JE = Junior exempt
- w/o = Walkover
- r = Retired
- d = Defaulted
- SR = Special ranking
Finals
| Semifinals | Final | ||||||||||||
| 1 | Daniela Di Toro Aniek van Koot
| 6 | 6 | ||||||||||
 Katharina Krüger Ju Yeon Park
| 2 | 2 | |||||||||||
| 1 | Daniela Di Toro Aniek van Koot
| 3 | 6 | [10] | |||||||||
| 2 | Esther Vergeer Sharon Walraven
| 6 | 3 | [4] | |||||||||
 Florence Gravellier Jiske Griffioen
| 5 | 4 | |||||||||||
| 2 | Esther Vergeer Sharon Walraven
| 7 | 6 | ||||||||||
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