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Andre Agassi was the defending champion, and won in the final 6–3, 3–6, 6–3, against Yevgeny Kafelnikov.
| Draw | |
|---|---|
| 2001 Colonial Classic | |
| Champion |  Andre Agassi |
| Runner-up |  Yevgeny Kafelnikov |
| Score | 6–3, 3–6, 6–3 |
Marat Safin (first round, withdrew due to an elbow injury)
Pete Sampras (first round, seventh place)- Yevgeny Kafelnikov (final, second place)
- Andre Agassi (champion, first place)
Juan Carlos Ferrero (semifinals, third place)
Patrick Rafter (first round, fifth place)
Nicolas Kiefer (first round, eighth place)
Nicolas Escudé (semifinals, fourth place)
Nicolás Lapentti (replaced Marat Safin, sixth place)
Key
- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- SE = Special exempt
- PR = Protected ranking
- ITF = ITF entry
- JE = Junior exempt
- w/o = Walkover
- r = Retired
- d = Defaulted
- SR = Special ranking
Main draw
| First round | Semifinals | Final (First/Second place match) | ||||||||||||||||||
| 1 | Marat Safin
| 2 | 1 | |||||||||||||||||
| 8 |  Nicolas Escudé
| 6 | 6 | |||||||||||||||||
| 8 | Nicolas Escudé
| 6 | 5 | 1 | ||||||||||||||||
| 4 | Andre Agassi
| 3 | 7 | 6 | ||||||||||||||||
| 4 | Andre Agassi
| 77 | 3 | 6 | ||||||||||||||||
| 7 |  Nicolas Kiefer
| 62 | 6 | 2 | ||||||||||||||||
| 4 | Andre Agassi
| 6 | 3 | 6 | ||||||||||||||||
| 3 | Yevgeny Kafelnikov
| 3 | 6 | 3 | ||||||||||||||||
| 6 |  Patrick Rafter
| 2 | 2 | |||||||||||||||||
| 3 | Yevgeny Kafelnikov
| 6 | 6 | |||||||||||||||||
| 3 | Yevgeny Kafelnikov
| 6 | 6 | Third/Fourth place match | ||||||||||||||||
| 5 |  Juan Carlos Ferrero
| 3 | 4 | |||||||||||||||||
| 5 | Juan Carlos Ferrero
| 6 | 6 | 8 | Nicolas Escudé
| 3 | 5 | |||||||||||||
| 2 | Pete Sampras
| 2 | 4 | 5 | Juan Carlos Ferrero
| 6 | 7 | |||||||||||||
Play-offs
| First round | Fifth/Sixth place match | ||||||||||||
| 9 |  Nicolás Lapentti
| 64 | 7 | 77 | |||||||||
| 7 | Nicolas Kiefer
| 77 | 5 | 62 | |||||||||
| 9 | Nicolás Lapentti
| 4 | 64 | ||||||||||
| 5 | Patrick Rafter
| 6 | 77 | ||||||||||
| 5 | Patrick Rafter
| 6 | 77 | ||||||||||
| 2 | Pete Sampras
| 4 | 65 | Seventh/Eighth place match | |||||||||
| 7 | Nicolas Kiefer
| 2 | 65 | ||||||||||
| 2 | Pete Sampras
| 6 | 77 | ||||||||||
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