11β-Methyl-19-nortestosterone dodecylcarbonate

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11β-Methyl-19-nortestosterone dodecylcarbonate

11β-Methyl-19-nortestosterone 17β-dodecylcarbonate (11β-MNTDC) (developmental code name CDB-4754) is a synthetic and orally active anabolic–androgenic steroid (AAS) and a derivative of nandrolone (19-nortestosterone) which was developed by the Contraceptive Development Branch (CDB) of the National Institute of Child Health and Human Development (NICHD) and has not been marketed for medical use at this time.[1][2][3][4] It is an androgen ester – specifically, the C17β dodecylcarbonate ester of 11β-methyl-19-nortestosterone (11β-MNT) – and acts as a prodrug of 11β-MNT in the body.[1][2][3][4]

Quick Facts Clinical data, Other names ...
11β-Methyl-19-nortestosterone dodecylcarbonate
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Clinical data
Other names11β-MNTDC; CDB-4754
Routes of
administration
By mouth, intramuscular injection
Drug classAndrogen; Anabolic steroid; Androgen ester; Progestogen
Identifiers
  • [(8R,9S,10R,11S,13S,14S,17S)-11,13-dimethyl-3-oxo-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl] dodecyl carbonate
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC32H52O4
Molar mass500.764 g·mol−1
3D model (JSmol)
  • CCCCCCCCCCCCOC(=O)O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3[C@@H](C)C[C@]12C
  • InChI=1S/C32H52O4/c1-4-5-6-7-8-9-10-11-12-13-20-35-31(34)36-29-19-18-28-27-16-14-24-21-25(33)15-17-26(24)30(27)23(2)22-32(28,29)3/h21,23,26-30H,4-20,22H2,1-3H3/t23-,26-,27-,28-,29-,30+,32-/m0/s1
  • Key:JVTCGMMASZPYDR-UIRZMXPTSA-N
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11β-MNTDC is under development as a birth control pill for men.[5][6][7]\ It has been described as the "sister compound" of dimethandrolone undecanoate, which is also under development as a birth control pill for men.[7][5]

Because 11β-MNTDC is not 5α-reduced, in contrast to testosterone, it may have less risk of scalp hair loss.[8]

See also

References

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