User:Mr. Ibrahem/Pfizer–BioNTech COVID-19 vaccine
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Pfizer–BioNTech COVID-19 vaccine, known by the generic name tozinameran and brand name Comirnaty, is a COVID-19 vaccine.[1] It is used in people over the age of four, eleven, or fifteen years depending on the jurisdictions, to provide protection against COVID-19.[1][20][21] It was initially found to be 95% effective.[1] It is given as at least two doses, by injection into a muscle, at least 21 days apart.[1]
Vaccine description | |
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Target | SARS-CoV-2 |
Vaccine type | mRNA |
Clinical data | |
Pronunciation | Tozinameran: /ˌtoʊzɪˈnæmərən/ TOH-zih-NAM-ər-ən |
Trade names | Comirnaty[1] |
Other names | BNT162b2, COVID-19 mRNA vaccine (nucleoside-modified) |
AHFS/Drugs.com | Monograph |
MedlinePlus | a621003 |
License data | |
Pregnancy category |
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Routes of administration | Intramuscular |
Drug class | COVID-19 vaccine[1] |
Legal status | |
Legal status |
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Most side effects are mild to moderate and resolve within a few days.[1] These may include pain at the injection site, tiredness, fever, diarrhea, headache, and muscle pains.[1] Rare side effects may include anaphylaxis, facial palsy, pericarditis, and myocarditis.[1] There is no evidence of harm with use in pregnancy.[22][23] It is an mRNA vaccine, composed of nucleoside-modified mRNA (modRNA) encoding the spike protein of SARS-CoV-2, which is encapsulated in lipid nanoparticles.[24]
The vaccine received emergency use authorization (EUA) in the United States in October 2020 and was approved for medical use in Europe in December 2020.[1][25] It received full approval in the United States in August 2021.[25] It has been authorized for use at some level in at least 151 countries as of 2022.[26] It was initially being sold to governments for between 15 and 25 USD per dose.[27] It was developed by the German company BioNTech and American company Pfizer.[28] It was the first COVID‑19 vaccine to be authorized by a stringent regulatory authority.[29][30] As of September 2021[update], more than 1.5 billion doses have been shipped worldwide.[31]