User:Mr. Ibrahem/Disopyramide
From Wikipedia, the free encyclopedia
Disopyramide, sold under the brand names Norpace among others, is a medication used to prevent ventricular tachycardia.[1] It is typically only used when other medications are not effective.[1] Use is not recommended for less serious arrhythmias.[1] It is taken by mouth.[1]
Clinical data | |
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Trade names | Norpace, Rythmodan, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682408 |
Pregnancy category |
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Routes of administration | By mouth |
Drug class | Class 1a anti-arrhythmic[1] |
Legal status | |
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Pharmacokinetic data | |
Bioavailability | High |
Protein binding | 50% to 65% (concentration-dependent) |
Metabolism | Liver (CYP3A4-mediated) |
Elimination half-life | 6.7 hours (range 4 to 10 hours) |
Excretion | Kidney (80%) |
Identifiers | |
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Chemical and physical data | |
Formula | C21H29N3O |
Molar mass | 339.483 g·mol−1 |
3D model (JSmol) | |
Melting point | 94.5 to 95 °C (202.1 to 203.0 °F) |
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Common side effects include dry mouth, constipation, blurry vision, urinary retention, nausea, tiredness, and dizziness.[1] Other side effects may include heart failure, arrhythmias, and low blood sugar.[1] Safety in pregnancy is unclear.[1] It is a class 1a anti-arrhythmic and sodium channel blocker.[1] It has a negative effect on the hearts ability to contract.[1]
Disopyramide was approved for medical use in the United States in 1977.[1] It is available as a generic medication.[2] In the United Kingdom 84 pills of 100 mg costs the NHS about £27 as of 2021.[2] In the United States this amount costs about 55 USD.[3]