User:Kalirren
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The Entner-Doudoroff pathways are routes of glucose metabolism alternative to the Embden-Meyerhof pathway. All of the Entner-Doudoroff pathways generate less ATP from a given amount of glucose than the Embden-Meyerhof pathway does.
There are three known variations of the Entner-Doudoroff pathway. All three involve the thematic steps of
1) oxidation of glucose to a δ-lactone, yielding NADPH,
2) hydrolysis of this lactone to yield a sugar acid,
3) dehydration of this sugar acid to yield a 2-keto-3-deoxy-gluconate, and
4) aldol cleavage of this 2-keto-3-deoxy-gluconate to yield pyruvate and a glyceraldehyde.
The differences between these variations involve the points at which the substrate is phosphorylated.
As in the Embden-Meyerhof pathway, the processes of the Entner-Doudoroff pathways also take place in the cytosol.