User:Bernanke's Crossbow/Schutzgruppe
From Wikipedia, the free encyclopedia
A protecting group is a chemical substituent that, when a complicated multistage chemical synthesis of a molecule is undertaken, temporarily protects an important functional group and so inhibits an undesirable reaction at the group. After execution of the desired reaction at another site in the molecule, the protecting group is detached. For many functional groups, many protecting groups are known, differing in their stability and the environments promoting their cleavage.
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In the synthesis of special there are standard choices of protecting groups. Protecting groups have nowadays become a very important tool in the synthesis of complex compounds.
The expectations of a protecting group are quite demanding. They include: that they must attach to a functional group with high yield and specificity and moreover must be cleavable in mild conditions. On both counts, the reaction conditions should be standardized. Moreover, the protecting group must be stable under many possible reaction conditions. Ideally, the constructed product should be easily detachable, and optimally the protecting-group reagent also be cheap. Indeed, the broader the applications of a protecting group, the better the aforementioned reactivities.