User:Mr. Ibrahem/Tucatinib
From Wikipedia, the free encyclopedia
Tucatinib, sold under the brand name Tukysa, a medication used to treat HER2-positive breast cancer.[4] Specifically it is used in cases which are localized but advanced or which have spread to other parts of the body.[4] It is used together with capecitabine and trastuzumab when other treatments have not worked.[4] It is taken by mouth.[4]
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Clinical data | |
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Pronunciation | too-KA-tih-nib |
Trade names | Tukysa |
Other names | ONT-380, ARRY-380 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a620032 |
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Routes of administration | By mouth |
Drug class | Tyrosine kinase inhibitor of human epidermal growth factor receptor 2 (HER2)[2][1] |
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Chemical and physical data | |
Formula | C26H24N8O2 |
Molar mass | 480.532 g·mol−1 |
3D model (JSmol) | |
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Common side effects include diarrhea, nausea, tiredness, inflammation of the mouth, liver problems, and rash.[4] A rash that may occur is known as palmar-plantar erythrodysesthesia.[2] Use during pregnancy may harm the baby.[1] It is a tyrosine kinase inhibitor of human epidermal growth factor receptor 2 (HER2).[2][1]
Tucatinib was approved for medical use in the United States and Australia in 2020,[2][1] and in Europe in 2021.[4] In the United States it costs about 21,000 USD per month as of 2021.[5]