Amidophosphoribosyltransferase (ATase), also known as glutamine phosphoribosylpyrophosphate amidotransferase (GPAT), is an enzyme that in humans is encoded by the PPAT (phosphoribosyl pyrophosphate amidotransferase) gene.[1][2]
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ATase is an enzyme that converts α-phosphoribosylpyrophosphate (α-PRPP) into 5-β-phosphoribosylamine. The enzyme uses the ammonia group from the glutamine side-chain. This is the committing step in de novo purine synthesis. It is allosterically inhibited by AMP, GMP, and IMP. 6TGMP (6-thioguanine monophosphate) is a pseudo inhibitor for ATase
ATase is a member of the purine/pyrimidine phosphoribosyltransferase family. This protein is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosynthesis.[1]
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
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Brayton KA, Chen Z, Zhou G, Nagy PL, Gavalas A, Trent JM, Deaven LL, Dixon JE, Zalkin H (Feb 1994). "Two genes for de novo purine nucleotide synthesis on human chromosome 4 are closely linked and divergently transcribed". The Journal of Biological Chemistry. 269 (7): 5313–21. doi:10.1016/S0021-9258(17)37689-5. PMID 8106516.
- Iwahana H, Oka J, Mizusawa N, Kudo E, Ii S, Yoshimoto K, Holmes EW, Itakura M (Jan 1993). "Molecular cloning of human amidophosphoribosyltransferase". Biochemical and Biophysical Research Communications. 190 (1): 192–200. doi:10.1006/bbrc.1993.1030. PMID 8380692.
- Gassmann MG, Stanzel A, Werner S (Nov 1999). "Growth factor-regulated expression of enzymes involved in nucleotide biosynthesis: a novel mechanism of growth factor action". Oncogene. 18 (48): 6667–76. doi:10.1038/sj.onc.1203120. PMID 10597272. S2CID 25419130.
- Chen S, Nagy PL, Zalkin H (May 1997). "Role of NRF-1 in bidirectional transcription of the human GPAT-AIRC purine biosynthesis locus". Nucleic Acids Research. 25 (9): 1809–16. doi:10.1093/nar/25.9.1809. PMC 146651. PMID 9108165.
- Stanley W, Chu EH (1978). "Assignment of the gene for phosphoribosylpyrophosphate amidotransferase to the pter leads to q21 region of human chromosome 4". Cytogenetics and Cell Genetics. 22 (1–6): 228–31. doi:10.1159/000130943. PMID 752480.
- Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Bera AK, Chen S, Smith JL, Zalkin H (Dec 1999). "Interdomain signaling in glutamine phosphoribosylpyrophosphate amidotransferase". The Journal of Biological Chemistry. 274 (51): 36498–504. doi:10.1074/jbc.274.51.36498. PMID 10593947. S2CID 46014989.
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- Zalkin H, Dixon JE (1992). "De novo purine nucleotide biosynthesis". Progress in Nucleic Acid Research and Molecular Biology. 42: 259–87. doi:10.1016/s0079-6603(08)60578-4. ISBN 9780125400428. PMID 1574589.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.