Uncle Tom's Cabin is an anti-slavery novel by Harriet Beecher Stowe.
Uncle Tom's Cabin may also refer to:
- "Uncle Tom's Cabin" (song), a 1990 song by Warrant from Cherry Pie
- Uncle Tom's Cabin Historic Site, an open-air museum and African American history centre near Dresden, Ontario, Canada
- Uncle Tom's Cabin, a pub in Wincanton, Somerset, England
- Uncle Tom's Cabin, a pub in Dundrum, Dublin, Republic of Ireland
- Riley-Bolten House, known locally as Uncle Tom's Cabin