Troponin C, skeletal muscle

Troponin C, skeletal muscle is a protein that in humans is encoded by the TNNC2 gene.^[5][6]

TNNC2
Identifiers
Aliases	TNNC2, troponin C2, fast skeletal type, CFAP85, FAP85
External IDs	OMIM: 191039; MGI: 98780; HomoloGene: 55727; GeneCards: TNNC2; OMA:TNNC2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 45,823,214 bp[1] End 45,833,745 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 164,619,081 bp[2] End 164,621,887 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis muscle of thigh gastrocnemius muscle thoracic diaphragm quadriceps femoris muscle vastus lateralis muscle Skeletal muscle tissue of biceps brachii body of tongue triceps brachii muscle deltoid muscle Top expressed in intercostal muscle soleus muscle medial head of gastrocnemius muscle masseter muscle tibialis anterior muscle body of femur thoracic diaphragm skeletal muscle tissue muscle of thigh ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding protein binding metal ion binding calcium-dependent protein binding actin filament binding calcium ion binding Cellular component cytosol troponin complex Biological process regulation of muscle contraction skeletal muscle contraction muscle filament sliding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7125 21925 Ensembl ENSG00000101470 ENSMUSG00000017300 UniProt P02585 P20801 RefSeq (mRNA) NM_003279 NM_009394 RefSeq (protein) NP_003270 NP_033420 Location (UCSC) Chr 20: 45.82 – 45.83 Mb Chr 2: 164.62 – 164.62 Mb PubMed search [3] [4]
Wikidata
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Troponin (Tn), is a key protein complex in the regulation of striated muscle contraction, composed of three subunits. The TnI subunit inhibits actomyosin ATPase, the TnT subunit binds tropomyosin and TnC, while the TnC subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin thin filaments. The protein encoded by the TNNC2 gene is the TnC subunit.^[6]