The African Queen may refer to:
- African Queen, a cultivar of Osteospermum, a member of the sunflower family
- African Queen (boat), the vessel used in the 1951 film The African Queen
- African Queen (ship), including a list of ships with the name
- The African Queen (novel), a 1935 novel by C. S. Forester
- The African Queen (film), a 1951 film adaptation starring Humphrey Bogart and Katharine Hepburn
- The African Queen (1977 film), a television film starring Warren Oates and Mariette Hartley
- African Queen, a 2021 album by Makhadzi
- African Queen, a 1981 album and song by Belgian pop group Allez Allez
- "African Queen", a version of Billy Ocean's 1984 song "Caribbean Queen"
- "African Queen", a song by 2face Idibia from the 2004 album Face 2 Face
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