| This article is substantially duplicated by a piece in an external publication. Please do not flag this article as a copyright violation of the following source: - Pharmacology and Abuse of Cocaine, Amphetamines, Ecstasy and Related Designer Drugs, 2010
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While researching sources for this article, I found the following text from the 2010 book "Pharmacology and Abuse of Cocaine, Amphetamines, Ecstasy and Related Designer Drugs" (Springer, isbn=978-90-481-2447-3), in the chapter "The Mushroom Psilocybin with Psychedelic Properties " by Enno Freye:
"The toxicity of psilocybin is relatively low; in rats, the oral LD50 is 280 mg/kg, approximately one and a half times that of caffeine. When administered intravenously in rabbits, psilocybin’s LD50 is approximately 12.5 mg/kg [138]. However, rabbits are extremely intolerant to the effects of most psychoactive drugs. The lethal dose from psilocybin intake alone is unknown at recreational or medicinal levels, and has never been documented; psilocybin makes up roughly 1% of the weight of Psilocybe cubensis mushrooms, and so nearly 1.7 kg of dried mushrooms, or 17 kg of fresh mushrooms, would be required for a 60 kg person to reach the 280 mg/kg LD50 rate of rats."
The wording is almost identical to the Wikipedia article. Worried that this was a copyvio, I checked the article history, and found that the Wikipedia text has been there since 2006—long before the publication of the book. I further checked their citation #138, Passie et al. (2002) "The pharmacology of psilocybin" Addiction Biology 7:357-64 (PMID 14578010). This source does support the LD50 of 280 mg/kg in rats, but does not mention one for rabbits. Note that the rest of the Freye paragraph is not cited. Thought I'd throw this out here in case in comes up in the future. Sasata (talk) 19:18, 2 March 2011 (UTC) |
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