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SH2 domain
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The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein[2] and in many other intracellular signal-transducing proteins.[3] SH2 domains bind to phosphorylated tyrosine residues on other proteins, modifying the function or activity of the SH2-containing protein. The SH2 domain may be considered the prototypical modular protein-protein interaction domain, allowing the transmission of signals controlling a variety of cellular functions.[4] SH2 domains are especially common in adaptor proteins that aid in the signal transduction of receptor tyrosine kinase pathways.[5]
Quick Facts Identifiers, Symbol ...
![]() Crystallographic structure of the SH2 domain. The structure consists of a large beta sheet (green) flanked by two alpha-helices (orange and blue).[1] | |||||||||
Identifiers | |||||||||
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Symbol | SH2 | ||||||||
Pfam | PF00017 | ||||||||
InterPro | IPR000980 | ||||||||
SMART | SH2 | ||||||||
PROSITE | PDOC50001 | ||||||||
SCOP2 | 1sha / SCOPe / SUPFAM | ||||||||
CDD | cd00173 | ||||||||
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