![cover image](https://wikiwandv2-19431.kxcdn.com/_next/image?url=https://upload.wikimedia.org/wikipedia/commons/thumb/4/42/Golimumab_5yoy.png/640px-Golimumab_5yoy.png&w=640&q=50)
Golimumab
Pharmaceutical drug / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about Simponi?
Summarize this article for a 10 year old
Golimumab, sold under the brand name Simponi, is a human monoclonal antibody which is used as an immunosuppressive medication.[3][5] Golimumab targets tumor necrosis factor alpha (TNF-alpha), a pro-inflammatory molecule[6] and hence is a TNF inhibitor. Profound reduction in C-reactive protein (CRP) levels, interleukin (IL)-6, intercellaular adhesion molecules (ICAM)-1, matrix metalloproteinase (MMP)-3, and vascular endothelial growth factor (VEGF) demonstrates golimumab as an effective modulator of inflammatory markers and bone metabolism.[7] Golimumab is given via subcutaneous injection.[3][5][8]
![]() Cartoon representation of the antibody golimumab's variable fragment. The heavy and light chain fragments are coloured blue and yellow, respectively. From PDB entry 5yoy | |
Monoclonal antibody | |
---|---|
Type | Whole antibody |
Source | Human |
Target | TNFα |
Clinical data | |
Trade names | Simponi, Simponi Aria |
Other names | CNTO-148[1] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a610010 |
License data | |
Pregnancy category |
|
Routes of administration | Subcutaneous injection |
ATC code | |
Legal status | |
Legal status | |
Identifiers | |
CAS Number | |
DrugBank |
|
ChemSpider |
|
UNII | |
KEGG |
|
ChEMBL | |
ECHA InfoCard | 100.226.360 ![]() |
Chemical and physical data | |
Formula | C6530H10068N1752O2026S44 |
Molar mass | 146945.25 g·mol−1 |
![]() ![]() |
It is on the World Health Organization's List of Essential Medicines.[9]