40S ribosomal protein S27a is a protein that in humans is encoded by the RPS27A gene.[5][6]
Quick Facts RPS27A, Available structures ...
RPS27A |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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2KTF, 2L0F, 2L0T, 2XK5, 3AXC, 3NHE, 3NOB, 3PHW, 3TBL, 4UG0, 4V6X, 5AJ0, 4R62, 5FLX, 4UJD, 4KZZ, 4UJC, 3J7P, 4KZY, 4D5L, 3J7R, 4D61, 4KZX, 4UJE, 5A2Q |
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Identifiers |
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Aliases | RPS27A, CEP80, HEL112, S27A, UBA80, UBC, UBCEP1, UBCEP80, ribosomal protein S27a |
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External IDs | OMIM: 191343; MGI: 1925544; HomoloGene: 37715; GeneCards: RPS27A; OMA:RPS27A - orthologs |
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Gene ontology |
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Molecular function | | Cellular component | | Biological process |
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- negative regulation of epidermal growth factor receptor signaling pathway
- interstrand cross-link repair
- nucleotide-excision repair, DNA damage recognition
- positive regulation of canonical Wnt signaling pathway
- tumor necrosis factor-mediated signaling pathway
- regulation of type I interferon production
- TRIF-dependent toll-like receptor signaling pathway
- Fc-epsilon receptor signaling pathway
- endosomal transport
- global genome nucleotide-excision repair
- NIK/NF-kappaB signaling
- G2/M transition of mitotic cell cycle
- stress-activated MAPK cascade
- transforming growth factor beta receptor signaling pathway
- macroautophagy
- negative regulation of canonical Wnt signaling pathway
- nucleotide-excision repair, DNA gap filling
- viral transcription
- error-free translesion synthesis
- regulation of tumor necrosis factor-mediated signaling pathway
- stimulatory C-type lectin receptor signaling pathway
- negative regulation of transforming growth factor beta receptor signaling pathway
- SRP-dependent cotranslational protein targeting to membrane
- JNK cascade
- regulation of transcription from RNA polymerase II promoter in response to hypoxia
- nucleotide-excision repair, DNA incision
- I-kappaB kinase/NF-kappaB signaling
- innate immune response
- Notch signaling pathway
- regulation of mRNA stability
- protein polyubiquitination
- negative regulation of apoptotic process
- negative regulation of transcription by RNA polymerase II
- virion assembly
- positive regulation of NF-kappaB transcription factor activity
- anaphase-promoting complex-dependent catabolic process
- negative regulation of type I interferon production
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- nucleotide-binding oligomerization domain containing signaling pathway
- intracellular transport of virus
- viral life cycle
- MyD88-dependent toll-like receptor signaling pathway
- error-prone translesion synthesis
- MAPK cascade
- fibroblast growth factor receptor signaling pathway
- ion transmembrane transport
- glycogen biosynthetic process
- positive regulation of apoptotic process
- translational initiation
- positive regulation of I-kappaB kinase/NF-kappaB signaling
- translesion synthesis
- transcription-coupled nucleotide-excision repair
- T cell receptor signaling pathway
- MyD88-independent toll-like receptor signaling pathway
- positive regulation of transcription by RNA polymerase II
- regulation of signal transduction by p53 class mediator
- positive regulation of epidermal growth factor receptor signaling pathway
- Wnt signaling pathway
- nucleotide-excision repair, DNA duplex unwinding
- nucleotide-excision repair, DNA incision, 5'-to lesion
- protein biosynthesis
- rRNA processing
- ERBB2 signaling pathway
- Wnt signaling pathway, planar cell polarity pathway
- nucleotide-excision repair, preincision complex assembly
- proteasome-mediated ubiquitin-dependent protein catabolic process
- protein folding
- negative regulation of G2/M transition of mitotic cell cycle
- protein ubiquitination
- protein deubiquitination
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- entry of bacterium into host cell
- transmembrane transport
- regulation of necroptotic process
- membrane organization
- endoplasmic reticulum mannose trimming
- cellular iron ion homeostasis
- regulation of hematopoietic stem cell differentiation
- protein targeting to peroxisome
- cytokine-mediated signaling pathway
- modification-dependent protein catabolic process
- interleukin-1-mediated signaling pathway
| Sources:Amigo / QuickGO |
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Wikidata |
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Close
Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi.[6]
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- Kirschner LS, Stratakis CA (2000). "Structure of the human ubiquitin fusion gene Uba80 (RPS27a) and one of its pseudogenes". Biochem. Biophys. Res. Commun. 270 (3): 1106–10. doi:10.1006/bbrc.2000.2568. PMID 10772958.
- Petersen BO, Wagener C, Marinoni F, et al. (2000). "Cell cycle– and cell growth–regulated proteolysis of mammalian CDC6 is dependent on APC–CDH1". Genes Dev. 14 (18): 2330–43. doi:10.1101/gad.832500. PMC 316932. PMID 10995389.
- Bolton D, Evans PA, Stott K, Broadhurst RW (2002). "Structure and properties of a dimeric N-terminal fragment of human ubiquitin". J. Mol. Biol. 314 (4): 773–87. doi:10.1006/jmbi.2001.5181. PMID 11733996.
- Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The Human Ribosomal Protein Genes: Sequencing and Comparative Analysis of 73 Genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Cohen BD, Bariteau JT, Magenis LM, Dias JA (2003). "Regulation of follitropin receptor cell surface residency by the ubiquitin-proteasome pathway". Endocrinology. 144 (10): 4393–402. doi:10.1210/en.2002-0063. PMID 12960054.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Li H, Seth A (2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene. 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250. S2CID 37253372.