The name Queenie is an affectionate, or pet use, of the term "queen", and is thought to be derived from the Old English word "cwen", meaning 'woman' rather than a reference to the monarch or his wife.
As a first name it can also mean "Royal Lady" or "Ruler". In this sense the name is also used as a nickname or pet name for a girl who shares her first name with a Queen. As such, it was popular name during the Victorian era in the British Empire. It was once very popular in London's East End.
- Queenie Chu (born 1981), Hong Kong television presenter and actress
- Q. D. Leavis (1900–1982), English literary critic and essayist
- Queenie McKenzie (c. 1930 – 1998), indigenous Australian artist
- Queenie Rosson (1889–1978), American silent film actress
- Queenie Smith (1898–1978), American stage, film and television actress
- Queenie Thomas (1898–1977), British actress
- Queenie Watts (1926–1980), English actress and singer
- Queenie Ashton (1903–1999), stage name of British-born soprano and English and Australian character actress Ethel Muriel Cover (née Ashton)
- Queenie Chong, Brunei businessperson and politician
- Queenie Leighton (1874–1943), stage name of British music hall star Lilian Caroline Augusta Rickard
- Queenie Leonard (1905–2002), stage name of English character actress and singer Pearl Walker
- Queenie, a performer in the English pop quintet King (pop band)
- Queenie Williams (1896–1962), stage name of Australian actress Alfreda Ina Williams
- Queenie, a character in the American television series American Horror Story
- Queenie or Queeney, a character in the Aubrey–Maturin series of novels by Patrick O'Brian
- Queenie (Blackadder), a caricature of Elizabeth I of England in the British TV series Blackadder
- Queenie, a dog in Truman Capote's short story "A Christmas Memory"
- Queenie, a character in The Curious Case of Benjamin Button (film)
- Queenie, a character in the musical Show Boat
- Queenie, a character in Joseph Moncure March's poem "The Wild Party" (poem)
- Queenie Gibbons, a character in Noël Coward's play This Happy Breed
- Queenie Goldstein, a character in Fantastic Beasts (film series)
- Queenie Kelley, the main character from Queenie (miniseries)
- Queenie Price, a character in the British soap opera EastEnders
- Magdalene "Queenie" Shaw, a character from the Fast & Furious franchise
- Queenie Yoh, a character in the 2018 Japanese anime Lost Hope (TV series)