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Precancerous condition
Condition or cell change indicating increased cancer risk / From Wikipedia, the free encyclopedia
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A precancerous condition is a condition, tumor or lesion involving abnormal cells which are associated with an increased risk of developing into cancer.[1][2][3] Clinically, precancerous conditions encompass a variety of abnormal tissues with an increased risk of developing into cancer. Some of the most common precancerous conditions include certain colon polyps, which can progress into colon cancer, monoclonal gammopathy of undetermined significance, which can progress into multiple myeloma or myelodysplastic syndrome.[4] and cervical dysplasia, which can progress into cervical cancer.[5] Bronchial premalignant lesions can progress to squamous cell carcinoma of the lung.[6]
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Precancerous condition | |
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Other names | Premalignant condition, precancer, premalignancy, dysplasia, intraepithelial neoplasm, carcinoma in situ |
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Micrograph of high grade squamous intraepithelial lesion, a precancerous condition of the uterine cervix. Pap stain. | |
Specialty | Oncology |
Pathologically, precancerous tissue can range from benign neoplasias, which are tumors which don't invade neighboring normal tissues or spread to distant organs, to dysplasia,[1] a collection of highly abnormal cells which, in some cases, has an increased risk of progressing to anaplasia and invasive cancer which is life-threatening. Sometimes, the term "precancer" is also used for carcinoma in situ, which is a noninvasive cancer that has not grown and spread to nearby tissue, unlike the invasive stage. As with other precancerous conditions, not all carcinoma in situ will become an invasive disease but is at risk of doing so.