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Pleckstrin homology domain
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Pleckstrin homology domain (PH domain) or (PHIP) is a protein domain of approximately 120 amino acids that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.[1][2][3][4][5][6][7]
![]() PH domain of tyrosine-protein kinase BTK | |||||||||
Identifiers | |||||||||
---|---|---|---|---|---|---|---|---|---|
Symbol | PH | ||||||||
Pfam | PF00169 | ||||||||
Pfam clan | CL0266 | ||||||||
InterPro | IPR001849 | ||||||||
SMART | PH | ||||||||
PROSITE | PDOC50003 | ||||||||
SCOP2 | 1dyn / SCOPe / SUPFAM | ||||||||
OPM superfamily | 49 | ||||||||
OPM protein | 1pls | ||||||||
CDD | cd00821 | ||||||||
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This domain can bind phosphatidylinositol lipids within biological membranes (such as phosphatidylinositol (3,4,5)-trisphosphate and phosphatidylinositol (4,5)-bisphosphate),[8] and proteins such as the βγ-subunits of heterotrimeric G proteins,[9] and protein kinase C.[10] Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways.