Pickup, pick-up or pick up may refer to:
- Pickup truck or pick-up truck, a light truck with an open-top rear cargo area
- Pickup (electromotive power), a device used by electric locomotives, trams, etc. to acquire electric power from overhead wires, third rails, etc.
- Pickup (music technology), an electromagnetic device which detects vibrations from a musical instrument
- Pickup tube, a type of cathode ray tube
- Magnetic pickup, an electromagnetic device returning electrical pulses generated by rotating gears
- Phonograph pickup, a transducer used for the playback of gramophone records on a turntable or phonograph
- Pickup forceps, a handheld, hinged instrument used for grasping and holding objects
- Pick-up notes or anacrusis, note or sequence of notes which precedes the first downbeat in a bar
- Pickup group or pickup band, a musical ensemble brought together for only a few performances
- Pick-Up (band), a Ukrainian alternative rock band
- "Pickup" (song), by MacKenzie Porter
- Ronald Pickup (1940–2021), British actor
- Thomas Pickup, rugby league footballer of the 1920s for Wakefield Trinity
- Tim Pickup (1948–2021), Australian rugby league footballer
- Shih-Te (fl. 9th century), a Tang Dynasty Chinese Buddhist poet (literally "Pick-Up" or "Foundling")
- Pickup artist, a man who is skilled in meeting, attracting, and seducing women
- Pick-up game, a game spontaneously started by a group of players
- Pick-up hockey, an informal type of ice hockey
- Pick-up line, a conversation opener to engage an unfamiliar person for romance or dating