Prostate-specific antigen
Mammalian protein found in humans / From Wikipedia, the free encyclopedia
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Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), P-30 antigen, is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland in men and the paraurethral glands in women.[5]
KLK3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | KLK3, APS, KLK2A1, PSA, hK3, kallikrein related peptidase 3, Prostate Specific Antigen | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 176820; MGI: 97320; HomoloGene: 68141; GeneCards: KLK3; OMA:KLK3 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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PSA is produced for the ejaculate, where it liquefies semen in the seminal coagulum and allows sperm to swim freely.[6] It is also believed to be instrumental in dissolving cervical mucus, allowing the entry of sperm into the uterus.[7]
PSA is present in small quantities in the serum of men with healthy prostates, but is often elevated in the presence of prostate cancer or other prostate disorders.[8] PSA is not uniquely an indicator of prostate cancer, but may also detect prostatitis or benign prostatic hyperplasia.[9]