Walker motifs
ATP-binding protein sequence motifs / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about P-loop?
Summarize this article for a 10 year old
SHOW ALL QUESTIONS
The Walker A and Walker B motifs are protein sequence motifs, known to have highly conserved three-dimensional structures. These were first reported in ATP-binding proteins by Walker and co-workers in 1982.[1]
Quick Facts P-loop containing nucleoside triphosphate hydrolase, Identifiers ...
Close
Of the two motifs, the A motif is the main "P-loop" responsible for binding phosphate, while the B motif is a much less conserved downstream region. The P-loop is best known for its presence in ATP- and GTP-binding proteins, and is also found in a variety of proteins with phosphorylated substrates. Major lineages include:[2][3][4][5]
- RecA and rotor ATP synthase / ATPases (α and β subunits).
- Nucleic acid-dependent ATPases: helicases, Swi2, and PhoH (InterPro: IPR003714)
- AAA proteins
- STAND NTPases including MJ, PH, AP, and NACHT ATPases
- ABC-PilT ATPases
- Nucleotide kinases (InterPro: IPR000850)
- G domain proteins: G-proteins (transducin), myosin.