P38 or P-38 may refer to:
Biology and medicine
- Multisynthetase complex auxiliary component p38
- p38 mitogen-activated protein kinases
- RPP38, ribonuclease P protein subunit p38
Military
- HMS P38 (1917), a P-class sloop of the Royal Navy
- HMS P38 (1941), a submarine of the Royal Navy
- Lockheed P-38 Lightning, an American fighter aircraft
- P-38 can opener, issued by the United States Armed Forces
- Walther P38, a pistol
Other uses
- Mitchell Wing P-38, an American ultralight aircraft
- Papyrus 38, a biblical manuscript
- Phosphorus-38, an isotope of phosphorus
- Range Rover (P38A), a SUV
- Porax-38, a starfighter from the Star Wars fictional universe
- P-38_can_opener, a small can opener
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