Origin recognition complex subunit 3 is a protein that in humans is encoded by the ORC3 (ORC3L) gene.[5][6][7]

Quick Facts Origin recognition complex (ORC) subunit 3 N-terminus, Identifiers ...
Origin recognition complex (ORC) subunit 3 N-terminus
Identifiers
SymbolORC3_N
PfamPF07034
InterProIPR010748
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
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Quick Facts Identifiers, Aliases ...
ORC3
Identifiers
AliasesORC3, LAT, LATHEO, ORC3L, origin recognition complex subunit 3
External IDsOMIM: 604972; MGI: 1354944; HomoloGene: 8225; GeneCards: ORC3; OMA:ORC3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001197259
NM_012381
NM_181837

NM_001159563
NM_015824

RefSeq (protein)

NP_001184188
NP_036513
NP_862820

NP_001153035
NP_056639

Location (UCSC)Chr 6: 87.59 – 87.67 MbChr 4: 34.57 – 34.61 Mb
PubMed search[3][4]
Wikidata
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Function

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.[7]

Interactions

ORC3 has been shown to interact with:

References

Further reading

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