Neurogenin-2 is a protein that in humans is encoded by the NEUROG2 gene.[5]
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Neurogenin-2 is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factor genes that play an important role in neurogenesis.[6]
It has been found to reprogram astrocytes to glutamergic neurons when expressed.[7]
- Gradwohl G, Fode C, Guillemot F (November 1996). "Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors". Developmental Biology. 180 (1): 227–241. doi:10.1006/dbio.1996.0297. PMID 8948587.
- Simmons AD, Horton S, Abney AL, Johnson JE (January 2001). "Neurogenin2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers". Developmental Biology. 229 (2): 327–339. doi:10.1006/dbio.2000.9984. PMID 11203697.
- Kumar M, Bagchi B, Gupta SK, Meena AS, Gressens P, Mani S (August 2007). "Neurospheres derived from human embryoid bodies treated with retinoic Acid show an increase in nestin and ngn2 expression that correlates with the proportion of tyrosine hydroxylase-positive cells". Stem Cells and Development. 16 (4): 667–681. doi:10.1089/scd.2006.0115. PMID 17784840.
- Deng S, Deng H, Le W, Xu H, Yang H, Deng X, et al. (January 2010). "Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease". Neuroscience Letters. 468 (3): 195–197. doi:10.1016/j.neulet.2009.10.078. PMID 19879328. S2CID 27698762.
- Park CH, Kang JS, Yoon EH, Shim JW, Suh-Kim H, Lee SH (March 2008). "Proneural bHLH neurogenin 2 differentially regulates Nurr1-induced dopamine neuron differentiation in rat and mouse neural precursor cells in vitro". FEBS Letters. 582 (5): 537–542. Bibcode:2008FEBSL.582..537P. doi:10.1016/j.febslet.2008.01.018. PMID 18242186. S2CID 33390799.
- Fode C, Gradwohl G, Morin X, Dierich A, LeMeur M, Goridis C, et al. (March 1998). "The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons". Neuron. 20 (3): 483–494. doi:10.1016/S0896-6273(00)80989-7. PMID 9539123. S2CID 16790307.