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NADPH—hemoprotein reductase
Enzyme / From Wikipedia, the free encyclopedia
In enzymology, a NADPH—hemoprotein reductase is an enzyme that catalyzes the chemical reaction
- NADPH + H+ + n oxidized hemoprotein
NADP+ + n reduced hemoprotein
Quick Facts Identifiers, EC no. ...
NADPH—hemoprotein reductase | |||||||||
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![]() NADPH-Cytochrome P450 reductase dimer, Rattus norvegicus | |||||||||
Identifiers | |||||||||
EC no. | 1.6.2.4 | ||||||||
CAS no. | 9023-03-4 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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The three substrates of this enzyme are NADPH, H+, and oxidized hemoprotein, whereas its two products are NADP+ and reduced hemoprotein. It has two cofactors: flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN).
This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with a heme protein as acceptor. The systematic name of this enzyme class is NADPH:hemoprotein oxidoreductase. Other names include cytochrome P450 reductase, ferrihemoprotein P-450 reductase, and NADPH-dependent cytochrome c reductase.