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NAD+ kinase
Enzyme / From Wikipedia, the free encyclopedia
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NAD+ kinase (EC 2.7.1.23, NADK) is an enzyme that converts nicotinamide adenine dinucleotide (NAD+) into NADP+ through phosphorylating the NAD+ coenzyme.[6] NADP+ is an essential coenzyme that is reduced to NADPH primarily by the pentose phosphate pathway to provide reducing power in biosynthetic processes such as fatty acid biosynthesis and nucleotide synthesis.[7] The structure of the NADK from the archaean Archaeoglobus fulgidus has been determined.[1]
NAD+ kinase | |||||||||
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![]() Ribbon diagram of NAD+ kinase in complex with substrates.[1] | |||||||||
Identifiers | |||||||||
EC no. | 2.7.1.23 | ||||||||
CAS no. | 9032-66-0 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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NADK | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | NADK, dJ283E3.1, NAD kinase | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 611616; MGI: 2183149; HomoloGene: 49724; GeneCards: NADK; OMA:NADK - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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In humans, the genes NADK[8] and MNADK[9] encode NAD+ kinases localized in cytosol[8] and mitochondria,[9] respectively. Similarly, yeast have both cytosolic and mitochondrial isoforms, and the yeast mitochondrial isoform accepts both NAD+ and NADH as substrates for phosphorylation.[10][11]