![cover image](https://wikiwandv2-19431.kxcdn.com/_next/image?url=https://upload.wikimedia.org/wikipedia/commons/thumb/3/3b/NAADP%252B.svg/640px-NAADP%252B.svg.png&w=640&q=50)
Nicotinic acid adenine dinucleotide phosphate
Chemical compound / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about NAADP?
Summarize this article for a 10 year old
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a Ca2+-mobilizing second messenger synthesised in response to extracellular stimuli. Like its mechanistic cousins, IP3 and cyclic adenosine diphosphoribose (Cyclic ADP-ribose), NAADP binds to and opens Ca2+ channels on intracellular organelles, thereby increasing the intracellular Ca2+ concentration which, in turn, modulates sundry cellular processes (see Calcium signalling). Structurally, it is a dinucleotide that only differs from the house-keeping enzyme cofactor, NADP by a hydroxyl group (replacing the nicotinamide amino group) and yet this minor modification converts it into the most potent Ca2+-mobilizing second messenger yet described. NAADP acts across phyla from plants to humans.
![]() | |
![]() | |
Identifiers | |
---|---|
3D model (JSmol) |
|
ChemSpider |
|
ECHA InfoCard | 100.164.946 ![]() |
PubChem CID |
|
| |
| |
Properties | |
[C21H28N6O18P3]+ | |
Molar mass | 745.398 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|