Michael or Mike Thomas may refer to:
- Michael M. Thomas (1936–2021), American novelist of financial thrillers
- Michael Tilson Thomas (born 1944), American conductor, pianist, and composer
- Michael Thomas (actor) (1952–2019), British actor
- Mike Thomas (author) (born 1971), British novelist, Pocket Notebook
- Michael Thomas (born 1981), Welsh heavy metal drummer of Bullet for My Valentine
- Michael Thomas (Man Gone Down author), American author
- Michael Damian Thomas, American magazine editor and podcaster
- Michael J Thomas, American saxophonist, songwriter, and vocalist
- Michael Thomas, former guitarist with the metal band Tuff
- Michael David Thomas (born 1933), former attorney general of Hong Kong
- Michael E. Thomas (1937–2018), university administrator and professor of industrial engineering
- Mike Thomas (politician) (born 1944), Labour Party member of the UK Parliament who defected to the SDP
- Michael C. Thomas (1948–2019), American entomologist
- Michael Thomas (academic) (born 1969), English professor and author in digital education
- Mike Thomas (athletic director), American university administrator
- Mike Seager Thomas, British archaeologist
- Michael Albert Thomas, Indian-American physicist, academic, and clinical researcher
- Michael Thomas (1858–1929), British zoologist better known as Oldfield Thomas