Mephenytoin
Chemical compound / From Wikipedia, the free encyclopedia
Mephenytoin (marketed as Mesantoin by Novartis) is a hydantoin, used as an anticonvulsant. It was introduced approximately 10 years after phenytoin, in the late 1940s. The significant metabolite of mephenytoin is nirvanol (5-ethyl-5-phenylhydantoin), which was the first hydantoin (briefly used as a hypnotic). However, nirvanol is quite toxic and mephenytoin was only considered after other less toxic anticonvulsants had failed. It can cause potentially fatal blood dyscrasia in 1% of patients.
Quick Facts Clinical data, AHFS/Drugs.com ...
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AHFS/Drugs.com | Micromedex Detailed Consumer Information |
MedlinePlus | a611020 |
Routes of administration | Oral |
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Metabolism | CYP2C19 |
Elimination half-life | 7 hours |
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ECHA InfoCard | 100.000.012 |
Chemical and physical data | |
Formula | C12H14N2O2 |
Molar mass | 218.256 g·mol−1 |
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Mephenytoin is no longer available in the US or the UK. It is still studied largely because of its interesting hydroxylation polymorphism.