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From Wikipedia, the free encyclopedia
In organic chemistry, the Malaprade reaction or Malaprade oxidation is a glycol cleavage reaction in which a vicinal diol is oxidized by periodic acid or a periodate salt to give the corresponding carbonyl functional groups.[1][2] The reaction was first reported by Léon Malaprade in 1928.[3][4] Amino alcohols are also cleaved.[5]
In terms of mechanism, the reaction is thought to proceed by a cyclic diester of iodine(VII).[6]
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