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Mucin short variant S1
Human protein / From Wikipedia, the free encyclopedia
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Mucin short variant S1, also called polymorphic epithelial mucin (PEM) or epithelial membrane antigen (EMA), is a mucin encoded by the MUC1 gene in humans.[3] Mucin short variant S1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs.[4] Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the pathogen from reaching the cell surface.[5] Overexpression of MUC1 is often associated with colon, breast, ovarian, lung and pancreatic cancers.[6] Joyce Taylor-Papadimitriou identified and characterised the antigen during her work with breast and ovarian tumors.