This is a list of state leaders in the 16th century BC (1600–1501 BC).
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- State leaders in the 17th century BC – State leaders in the 15th century BC – State leaders by year
Egypt: Second Intermediate Period
- Nebiriau II, King (c.1600 BC)
- Semenre, King (c.1600 BC)
- Bebiankh, King (c.1600–1588 BC)
- Sekhemre Shedwast, King (early-16th century BC)
- Dedumose I, King (c.1590 BC)
- Dedumose II, King (c.1590 BC)
- Djedankhre Montemsaf, King (c.1590 BC)
- Merankhre Mentuhotep, King (c.1585 BC)
- Senusret IV, King (early-16th century BC)
- Pepi III, King (uncertain chronological position)
- Rahotep, King (1580–1576 BC)
- Nebmaatre, King (1570s BC)
- Sobekemsaf I, King (1570s BC)
- Sobekemsaf II, King (1570s BC)
- Sekhemre-Wepmaat Intef, King (c.1573–c.1571 BC)
- Nubkheperre Intef, King (c.1571–1560s BC)
- Sekhemre-Heruhirmaat Intef, King (1560s BC)
- Senakhtenre Ahmose, King (1559–1558 BC)
- Seqenenre Tao, King (c.1560/1558–c.1554 BC)
- Kamose, King (c.1555–1550/1549 BC)
Egypt: New Kingdom
Asia: Southeast
Vietnam
- Khôn line, (c.1632–c.1431 BC)
Asia: West
- Sharma-Adad II, King (1601–1598 BC)
- Erishum III, King (1598–1586 BC, traditional date, c.1580–1567 BC, newer dating)
- Shamshi-Adad II, King (1567–1561 BC)
- Ishme-Dagan II, King (1561–1545 BC)
- Shamshi-Adad III, King (1545–1529 BC)
- Puzur-Ashur III, King (1521–1498 BC)
- Shirtuh
- Kuduzulush II
- Sukkalmah & King of Susa
- Tan-Uli
- Sukkalmah & Sukkal
- Temti-Halki
- Sukkalmah & Sukkal of Elam and Simashki and Susa
- Kuk-Nashur IV
- Sukkalmah
- Kutik-Matlat
- Sukkalmah, ruler (c.1500 BC)