O'Driscoll made his international debut on 12 June 1999 against Australia at the Ballymore Stadium in Brisbane. He scored his first try for Ireland during his fourth match, against the United States in the 1999 Rugby World Cup at Lansdowne Road.[8] It was the first of 19 tries O'Driscoll scored there (including 2 after the venue was redeveloped as the Aviva Stadium) which, as of February 2018[update], is a record.[9] O'Driscoll went on to score tries in the 2003, 2007 and 2011 Rugby World Cup tournaments. His 33rd international try earned him the IRPA Try of the Year award in 2008 for a team try scored during Ireland's 18–12 defeat against Australia. Starting from a lineout inside their own 22, Ireland caught their own kick as they moved up to the halfway line. An exchange of passes culminated with O'Driscoll receiving the ball 9 metres (10yd) out before scoring.[10][11]
O'Driscoll scored multiple tries in a single international on six occasions, included in these were two hat-tricks. The first of these was scored against France during the 2000 Six Nations and the second came against Scotland in the 2002 Six Nations. O'Driscoll, who scored tries against all of the "Tier 1" nations, was most prolific against France, scoring eight times.[12]
Won denotes that the match was won by the side O'Driscoll was playing for.
Lost denotes that the match was lost by the side O'Driscoll was playing for.
Drawn denotes that the match was drawn.
* denotes the try was scored while playing for the British & Irish Lions.