DNA ligase 3
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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DNA ligase 3 also DNA ligase III, is an enzyme that, in humans, is encoded by the LIG3 gene.[5][6] LIG3 encodes ATP-dependent DNA ligases that seal interruptions in the phosphodiester backbone of duplex DNA.
There are three families of ATP-dependent DNA ligases in eukaryotes.[7] These enzymes utilize the same three step reaction mechanism; (i) formation of a covalent enzyme-adenylate intermediate; (ii) transfer of the adenylate group to the 5' phosphate terminus of a DNA nick; (iii) phosphodiester bond formation. Unlike LIG1 and LIG4 family members that are found in almost all eukaryotes, LIG3 family members are less widely distributed.[8] LIG3 encodes several distinct DNA ligase species by alternative translation initiation and alternative splicing mechanisms that are described below.